منابع مشابه
SURVEY AND SUMMARY Chromatin disruption and modification
Chromatin disruption and modification are associated with transcriptional regulation by diverse coactivators and corepressors. Here we discuss the possible structural basis and functional consequences of the observed alterations in chromatin associated with transcriptional activation and repression. Recent advances in defining the roles of individual histones and their domains in the assembly a...
متن کاملChromatin modification and disease.
“Physicians consider that when they have discovered the cause of disease, they have also discovered the method of treating it.” Cicero, Tusculan Disputations, III.x.23. In the last few years, the exciting realisation in the field of gene regulation is that transcription factors can function by recruiting large, multiprotein complexes which mediate several types of chromatin modification and rem...
متن کاملEpigenetic Modification of Plant Chromatin
Based on the analysis of 20 different monocot and eudicot species, we propose that the centromeric distribution of the phosphorylated histone H2AThr120 is evolutionary highly conserved across species with monoand holocentric chromosomes. Therefore, antibodies recognizing the phosphorylated threonine 120 of the histone H2A can serve as a universal marker for the cytological detection of centrome...
متن کاملHistone modification and replacement in chromatin activation.
Histones are subject to a complex and dynamic set of covalent modifications that are thought to be involved in the modulation of transcription during development, in X chromosome inactivation in female mammals, and in genome stability and meiotic chromosome dynamics. Histone modifications reported to date include acetylation, phosphorylation, methylation, ADP ribosylation, and ubiquitination (F...
متن کاملTranscriptional control: Repression by local chromatin modification
It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression complexes that include chromatin modification factors.
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1999
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/27.3.711